Resumos Bibliográficos
Coletados pelo Dr. Clayton Aguiar
Brief Report
The Treatment Initiation Program: An Intervention to Improve Depression Outcomes in Older Adults
Jo Anne Sirey, Ph.D., Martha L. Bruce, Ph.D., M.P.H., and George S. Alexopoulos, M.D.
OBJECTIVE: This pilot study tests the usefulness of the Treatment Initiation Program (TIP) to improve depression in older adults. The TIP is an individualized, early intervention to address older adults’ attitudes (e.g., perceived need for care and stigma) about depression and treatment. METHOD: Older adults with major depression seeking mental health treatment were randomly assigned to either pharmacotherapy alone or with the TIP. Severity was assessed with the Hamilton Depression Rating Scale at admission and at 6, 12, and 24 weeks. Mixed-effects models were calculated to evaluate the effects of the TIP. RESULTS: In mixed-effects models, TIP patients had a greater decrease in depression severity and reported less hopelessness than the patients receiving usual care. TIP patients were more likely to remain in t reatment 12 and 24 weeks after seeking care. CONCLUSIONS: These data support the usefulness of the TIP to improve depression outcomes and treatment participation among older adults.
Fonte: Am J Psychiatry 162:184-186, January 2005
Age- and Stage-dependent Accumulation of Advanced Glycation End Products in Intracellular Deposits in Normal and Alzheimer's Disease Brains
Hans-Joachim Lüth1, Vera Ogunlade2, Björn Kuhla3, Rosemarie Kientsch-Engel4, Peter Stahl4, Julie Webster5, Thomas Arendt1 and Gerald Münch3
1 Department of Neuroanatomy, Paul Flechsig Institute of Brain Research, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany, 2 Department of Neuropathology, Institute of Pathology, University of Leipzig, Liebigstrasse 26, 04103 Leipzig, Germany, 3 Neuroimmunological Cell Biology Unit, IZKF Leipzig, Inselstrasse 22, 04103 Leipzig, Germany, 4 Roche Diagnostics GmbH, 82372 Penzberg, Germany and 5 Comparative Genomics Centre, James Cook University, Townsville 4811, Australia
In this immunohistochemical study, the age- and stage-dependent accumulation of advanced glycation end-products (AGEs) in Alzheimer's disease (AD) and their relation to the formation of neurofibrillary tangles and neuronal cell death was investigated. For this purpose, the distribution of AGEs in neurons and glia was analyzed in the auditory association area of superior temporal gyrus (Brodmann area 22) of young and old non-demented controls and compared with early- and late-stage AD. A possible co-localization of AGEs with typical hallmarks of AD, such as hyperphosphorylated tau (as a marker for disturbed kinase/phosphatase activity), nNOS (as a marker for nitroxidative stress) and caspase-3 (as a marker of apoptotic cell death), was also investigated. Our results show that the percentage of AGE-positive neurons (and as troglia) increase both with age and, in AD patients, with the progression of the disease (Braak stages). Interestingly, nearly all if those neurons which show diffuse cytosolic AGE immunoreactivity also contain hyperphosphoryated tau, suggesting a link between AGE accumulation and the formation of early neurofibrillary tangles. Many, but not all, neurons show a co-localization of AGEs with othermarkers of neurodegeneration, such as nNOS and caspase-3.
Fonte: Cerebral Cortex 2005 15(2):211-220; doi:10.1093/cercor/bhh123
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